Reaction Steps
(S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea (0.0499 g, 0.122 mmol) in dry N,N-Dimethylformamide (0.60 mL, 7.7 mmol) was added N,N-Diisopropylethylamine (0.0636 mL, 0.365 mmol) followed by Methanesulfonyl chloride (0.01410 mL, 0.1822 mmol). The reaction mixture was stirred for 1 hour then submitted for purification. 1H NMR (400 MHz, DMSO) δ 8.65 (s, 1H), 8.16 (d, J=8.7, 2H), 7.48 (d, J=8.8, 2H), 6.18 (t, J=5.5, 1H), 4.32 (dd, J=36.6, 17.0, 2H), 4.01 (s, 1H), 3.85 (d, J=10.7, 1H), 3.79 (d, J=11.4, 1H), 3.68 (dd, J=20.5, 8.8, 2H), 3.59-3.49 (m, 2H), 3.43 (t, J=11.0, 1H), 3.26-3.17 (m, 1H), 3.16-3.06 (m, 2H), 3.02 (s, 3H), 2.94-2.81 (m, 1H), 2.77-2.63 (m, 1H), 1.88-1.69 (m, 2H), 1.06 (t, J=7.2, 3H), 0.83 (t, J=7.4, 3H). LC/MS-m/z+489.2 (M+H)+.
