反应详情

Tert-butyl 4-[5-(6-Methoxy-1,3-benzothiazol-2-yl)pyridin-2-yl]piperazine-1-carboxylate was prepared according to the method used for the preparation of 2-[6-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-3-pyridinyl]-6-benzothiazolecarboxylic acid ethyl ester, from 2-bromo-6-methoxybenzothiazole (Yang et al. J. Biological Chem. 1989, 2, 891-898) (0.20 g), and obtained as a solid (0.23 g). 1H NMR δ 8.74 (s, 1H) 8.12 (d, 1H) 7.87 (d, 1H) 7.67 (s, 1H) 7.09 (dd, 1H) 6.98 (d, 1H) 3.84 (s, 3H) 3.64 (br. s., 4H) 3.45 (br. s., 4H) 1.43 (s, 9H); MS m/z M+H 427.