Sodium Hydroxide → HCID 24803238, compound

Participants

Reaction Steps

6-Methoxy-2-(6-piperazin-1-ylpyridin-3-yl)-1,3-benzothiazole was prepared according to the method used for the preparation of ethyl 2-(6-piperazin-1-ylpyridin-3-yl)-1,3-benzothiazole-6-carboxylate trifluoroacetate, from tert-butyl 4-[5-(6-methoxy-1,3-benzothiazol-2-yl)pyridin-2-yl]piperazine-1-carboxylate (0.22 g), with the exception that sodium hydroxide was used instead of sat. sodium hydrogencarbonate after completion of the reaction, and that the product was taken up in DCM thereafter. The title compound was obtained as a solid (0.15 g) after drying and concentration. 1H NMR δ 8.71 (d, 1H) 8.07 (dd, 1H) 7.85 (d, 1H) 7.66 (d, 1H) 7.09 (dd, 1H) 6.93 (d, 1H) 3.84 (s, 3H) 3.47-3.64 (m, 4H) 2.65-2.89 (m, 4H); MS m/z (M+H) 327.

Provenance & Evidence