反应详情

tert-Butyl 4-[5-(6-nitro-1,3-benzothiazol-2-yl)pyridin-2-yl]piperazine-1-carboxylate (90 mg, 0.2 mmol) was dissolved in methanol (8 mL). After addition of 7M NH3 in methanol (2 mL), palladium on carbon (10%, 10 mg) was added and the flask was evacuated and filled with hydrogen gas. The reaction mixture was shaken under an atmosphere of hydrogen overnight. The mixture was thereafter filtered through diatomaceous earth and evaporated in vacuo. The crude product was purified by flash column chromatography (heptane:ethyl acetate; 70:30 to 35:65), to give the title compound (38 mg) as a solid. MS m/z (M+H) 412.

1. additionwas added
2. customthe flask was evacuated
3. additionfilled with hydrogen gas
4. filtrationThe mixture was thereafter filtered through diatomaceous earth
5. customevaporated in vacuo
6. customThe crude product was purified by flash column chromatography (heptane:ethyl acetate; 70:30 to 35:65)