HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Methylmorpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Propylphosphoric anhydride | HCID 16167369 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Solvent | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Product | 4-Methylmorpholine | HCID 7972 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
| Product | Propylphosphoric anhydride | HCID 16167369 | — |
Reaction Steps
reacting (V) with an activating agent such as propylphosphonic anhydride or CDI (N,N-carbonyldiimidazole), (preferably propylphosphonic anhydride), and an amine of the formula (VI) in the presence of an amine base such as N-methylmorpholine, triethylamine, or diisopropylethylamine, in a suitable polar aprotic solvent such as DMF, or NMP, DMAC, DMPU to provide (I), and subsequently isolating (I),
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163918B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-c55159d4e1964e3f8e04a2f7b0aaa55a |
| Source note | uspto-grants-2012_04 |