HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine | HCID 59278357 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide | HCID 58084244 | — |
Reaction Steps
To a solution of 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine (0.920 g, 4.31 mmol) in dichloromethane (50 mL) was added 65% m-chloroperbenzoic acid (1.26 g, 4.75 mmol). After 2 hours, the mixture was diluted with EtOAc and water. The organic layer was washed with saturated aqueous NaHCO3, brine, dried over sodium sulfate, filter and concentrated to afford 1-(4-fluorophenyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163918B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-c9ef433ad9af422b9dd9187eca14acc8 |
| Source note | uspto-grants-2012_04 |