2-Butyloxirane → HCID 67266629, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, 30 ml of DMF was added to L-ascorbic acid (5.00 g), and further, 1,2-epoxyhexane (3.45 g) was added thereto. The mixture was heated up to 80° C. and stirred for 24 hours, then, extracted with ethyl acetate. The extracted liquid was dried over anhydrous sodium sulfate, then, concentrated under reduced pressure. Thereafter, 7.56 g of the resultant residue was subjected to silica gel column chromatography. Elution was performed with chloroform/methanol/water(volume ratio:20/3/0.3), and concentration was performed under reduced pressure to obtain 3-O-(2-hydroxyhexyl) ascorbic acid (1.93 g).

Provenance & Evidence