Benzyl Bromide → HCID 131729660, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, 3-O-ethylglyceryl ascorbic acid (3.03 g) obtained in Example 7 was stirred in DMSO (10 mL), and further, sodium hydrogen carbonate (0.92 g) and benzyl bromide (1.79 g) were added. The mixture was heated up to 100° C. and stirred for 5 hours, followed by extraction with ethyl acetate. Then, the extracted liquid was dried over anhydrous sodium sulfate, and concentrated under reduced pressure, and 2.16 g of the resultant residue was subjected to silica gel column chromatography. Elution was performed with chloroform/methanol/water(volume ratio:20/3/0.3), and concentration was performed under reduced pressure to obtain 3-O-ethylglyceryl-2-O-butyl ascorbic acid (0.89 g).

Provenance & Evidence