1-Bromohexadecane → HCID 131729664, compound

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere, 3-O-octylglyceryl ascorbic acid (5.17 g) obtained in Example 8 was stirred in DMSO (10 mL), and further, sodium hydrogen carbonate (1.20 g) and hexadecyl bromide (5.22 g) were added. The mixture was heated up to 100° C. and stirred for 3 hours, followed by extraction with ethyl acetate. Then, the extracted liquid was dried over anhydrous sodium sulfate, and concentrated under reduced pressure, and 9.06 g of the resultant residue was subjected to silica gel column chromatography. Elution was performed with chloroform/methanol/water(volume ratio:50/310.3), and concentration was performed under reduced pressure to obtain 3-O-octylglyceryl-2-O-hexadecyl ascorbic acid (3.41 g).

Provenance & Evidence