HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → {(3R*,5S*)-5-[Cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-piperidin-3-yl}-carbamic acid 2-methoxy-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Methoxyethyl chloroformate | HCID 69400 | — |
| Reactant | (3R*,5S*)-3-amino-5-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester | HCID 69066294 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | {(3R*,5S*)-5-[Cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-piperidin-3-yl}-carbamic acid 2-methoxy-ethyl ester | HCID 15984735 | — |
Reaction Steps
The title compound is prepared analogously as described in Example 61 using (3R*,5S*)-3-amino-5-[cyclopropyl-(2,3-dichloro-benzyl)-carbamoyl]-piperidine-1 carboxylic acid 9H-fluoren-9-ylmethyl ester; hydrochloride and 2-methoxyethyl chloroformate. MS (LC-MS): 444.2/446.1 [M+H]+; tR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, flow 1.5 ml/min): 4.74 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163773B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-8161e1e2a9cb4e0e835d4d71e1d293cb |
| Source note | uspto-grants-2012_04 |