HRID1698330

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID62493

2,2-Dimethylpropanoyl chloride

C5H9ClO

HCID84468

Trifluoroacetate

C2F3O2-

结构：CCN(C(=O)[C@H]1C[C@@H](N)CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1)c1ccc2c(c1)N(CCCOC)C(=O)CO2

HCID69071792

未命名化合物

PRODUCTS

生成物

结构：CCN(C(=O)[C@@H]1CNC[C@H](NC(=O)C(C)(C)C)C1)c1ccc2c(c1)N(CCCOC)C(=O)CO2

HCID15984738

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The title compound is prepared analogously as described in Example 61 using (3R*,5S*)-3-amino-5-{ethyl-[4-(3-methoxy-propyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-carbamoyl}-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester, trifluoroacetate and pivaloyl chloride. MS: 475.4 [M+H]+; tR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, flow 1.5 ml/min): 4.29 min.

WORKUP

后处理

custom4.29 min.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-69b4dd78e86441e09c8d9888403ca4df
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08163773B2
来源说明: uspto-grants-2012_04

反应 SMILES

C1C2C(COC([N:18]3[CH2:23][C@@H:22]([C:24](=[O:44])[N:25]([CH2:42][CH3:43])[C:26]4[CH:27]=[CH:28][C:29]5[O:34][CH2:33][C:32](=[O:35])[N:31]([CH2:36][CH2:37][CH2:38][O:39][CH3:40])[C:30]=5[CH:41]=4)[CH2:21][C@@H:20]([NH2:45])[CH2:19]3)=O)C3C(=CC=CC=3)C=2C=CC=1.FC(F)(F)C([O-])=O.[C:53](Cl)(=[O:58])[C:54]([CH3:57])([CH3:56])[CH3:55]>CC#N>[CH2:42]([N:25]([C:26]1[CH:27]=[CH:28][C:29]2[O:34][CH2:33][C:32](=[O:35])[N:31]([CH2:36][CH2:37][CH2:38][O:39][CH3:40])[C:30]=2[CH:41]=1)[C:24]([C@H:22]1[CH2:21][C@@H:20]([NH:45][C:53](=[O:58])[C:54]([CH3:57])([CH3:56])[CH3:55])[CH2:19][NH:18][CH2:23]1)=[O:44])[CH3:43]