HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-Methoxy-5-(3-methoxy-propoxy)-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | [3-Methoxy-5-(3-methoxypropoxy)phenyl]methanol | HCID 59817758 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Methoxy-5-(3-methoxy-propoxy)-benzaldehyde | HCID 59817759 | — |
Reaction Steps
The title compound is synthesized by MnO2 oxidation of [3-Methoxy-5-(3-methoxy-propoxy)-phenyl]-methanol (4.20 g, 18.6 mmol) in toluene at RT for 12 h. Yellow oil; MS: 225 [M+H]+; tR (HPLC, CombiScreen ODS-AM 50×4.6 mm; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 5 min then 100% CH3CN+0.1% TFA for 2 min, flow 2.0 ml/min): 3.59 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163773B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-4d124730a1c54d58ba0158ce2dcc35c2 |
| Source note | uspto-grants-2012_04 |