HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → N-(3-methoxy-5-(3-methoxypropoxy)benzyl)cyclopropanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 3-Methoxy-5-(3-methoxy-propoxy)-benzaldehyde | HCID 59817759 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(3-methoxy-5-(3-methoxypropoxy)benzyl)cyclopropanamine | HCID 59817709 | — |
Reaction Steps
The title compound is synthesized by reductive amination of 3-Methoxy-5-(3-methoxy-propoxy)-benzaldehyde (2.50 g, 11.1 mmol) with cyclopropylamine (855 mg, 15.0 mmol) analogously to the preparation of Example 152. Yellow oil; MS: 266 [M+H]+; tR (HPLC, CombiScreen ODS-AM 50×4.6 mm; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 5 min then 100% CH3CN+0.1% TFA for 2 min, flow 2.0 ml/min): 2.48 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163773B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-d762280aee18431fbee256841a2f242d |
| Source note | uspto-grants-2012_04 |