Pivaloyl chloride → HCID 57870343, compound

HRID 1698375Notes

Reaction equation

HRID 1698375 reaction equation
C1C2C(COC([N:18]3[CH2:23][C@@H:22]([NH:24][CH2:25][CH:26]4[CH2:28][CH2:27]4)[CH2:21][C@@H:20]([C:29](=[O:49])[N:30]([CH:46]4[CH2:48][CH2:47]4)[CH2:31][C:32]4[C:40]5[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=5)[N:34]([CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=4)[CH2:19]3)=O)C3C(=CC=CC=3)C=2C=CC=1.[C:50](Cl)(=[O:55])[C:51]([CH3:54])([CH3:53])[CH3:52]>CC#N>[CH:46]1([N:30]([CH2:31][C:32]2[C:40]3[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=3)[N:34]([CH2:41][CH2:42][CH2:43][O:44][CH3:45])[CH:33]=2)[C:29]([C@@H:20]2[CH2:21][C@H:22]([N:24]([CH2:25][CH:26]3[CH2:27][CH2:28]3)[C:50](=[O:55])[C:51]([CH3:54])([CH3:53])[CH3:52])[CH2:23][NH:18][CH2:19]2)=[O:49])[CH2:47][CH2:48]1

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 67273380(3R,5S)-3-{Cyclopropyl-[1-(3-methoxy-propyl)-1H-indol-3-ylmethyl]-carbamoyl}-5-(cyclopropylmethyl-amino)-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Product 1

HCID 57870343HCID 57870343, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent3×

Procedure

The title compound is prepared analogously as described in Example ??? using (3R,5S)-3-{Cyclopropyl-[1-(3-methoxy-propyl)-1H-indol-3-ylmethyl]-carbamoyl}-5-(cyclopropylmethyl-amino)-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester and pivaloylchloride. MS: 523 [M+H]+; tR (HPLC, ACQUITY UPLC™ BEH C18 1.7 μm, 50×2.1 mm; 5% CH3CN+0.1% TFA/H2O+0.1% TFA for 0.5 min then 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 5 min then 100% CH3CN+0.1% TFA for 1.5 min, flow 0.5 ml/min): 3.24 min.

Workup

  1. custom3.24 min.

Sources & evidence

ORD record
ord-7cdfdf3bbbb0452c8256943d622416cb
Source dataset
uspto-grants-2012_04
Patent number
US08163773B2

Reaction notes

Loading…