Hydrochloric Acid → HCID 67272964, compound

Participants

Reaction Steps

(3S,5R)-3-tert-Butoxycarbonylamino-5-{cyclopropyl-[4-(3-methoxy-propyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-carbamoyl}-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester (3.0 g, 4.0 mmol) is treated with 4N HCl in 1,4-dioxane (15 mL). The solution is concentrated under reduced pressure to give the title compound as a yellow powder. MS: 653 [M+H]+; tR (HPLC, ACQUITY UPLC™ BEH C18 1.7 μm, 50×2.1 mm; 5% CH3CN+0.1% TFA/H2O+0.1% TFA for 0.5 min then 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 5 min then 100% CH3CN+0.1% TFA for 1.5 min, flow 0.5 ml/min): 3.46 min.

Provenance & Evidence