4-Iodobenzoic acid → HCID 67276142, compound

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 300 mg (1 mmol) of 1-[3-tert-butyl-4-(ethylisobutylamino)phenyl]prop-2-yn-1-ol with 216 mg (0.87 mmol) of 4-iodobenzoic acid, 12 mg (0.04 mmol) of copper iodide and 15 mg (0.02 mmol) of bis(triphenylphosphine)palladium chloride. 190 mg of 4-{[tert-butyl(ethylisobutylamino)phenyl]hydroxyprop-1-ynyl}benzoic acid are obtained in the form of a beige solid (Mp=117° C., yield=53%).

Provenance & Evidence