HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Tert-butyl-4-dimethylaminobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | (4-Bromo-2-tert-butylphenyl)dimethylamine | HCID 67276232 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 3-Tert-butyl-4-dimethylaminobenzaldehyde | HCID 86646566 | 60.9% |
Reaction Steps
In a manner analogous to example 1 d, the process is carried out by a reaction of 4.1 g (16 mmol) of (4-bromo-2-tert-butylphenyl)dimethylamine with 9.6 ml (24 mmol) of a 2.5M solution of n-butyllithium and 1.9 ml (24 mmol) of DMF. 2 g of 3-tert-butyl-4-dimethylaminobenzaldehyde are obtained in the form of a yellow oil (yield=100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163952B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6415bc0d5704446099a808e6ef7edb82 |
| Source note | uspto-grants-2012_04 |