Dimethylformamide → 3-(1,1-Dimethylethyl)-4-(1-pyrrolidinyl)benzaldehyde

Participants

Reaction Steps

In a manner analogous to example 1 d, the process is carried out by a reaction of 7.6 g (27 mmol) of 1-(4-bromo-2-tert-butylphenyl)pyrrolidine with 16.2 ml (40 mmol) of a 2.5M solution of n-butyllithium and 3.1 ml (40 mmol) of DMF. 5 g of 3-tert-butyl-4-pyrrolidin-1-ylbenzaldehyde are obtained in the form of a yellow oil (yield=80%).

Provenance & Evidence