3-(1,1-Dimethylethyl)-4-(1-pyrrolidinyl)benzaldehyde → HCID 86646568, compound

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 1 g (4 mmol) of 3-tert-butyl-4-pyrrolidin-1-ylbenzaldehyde with 11 ml (5.5 mmol) of a 0.5M solution of ethynylmagnesium bromide. 640 mg of 1-(3-tert-butyl-4-pyrrolidin-1-ylphenyl)prop-2-yn-1-ol are obtained in the form of a colourless oil (yield=62%).

Provenance & Evidence