4-Iodobenzoic acid → HCID 25109558, compound

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 640 mg (2.5 mmol) of 1-(3-tert-butyl-4-pyrrolidin-1-ylphenyl)prop-2-yn-1-ol with 520 mg (2.1 mmol) of 4-iodobenzoic acid, 20 mg (0.1 mmol) of copper iodide and 37 mg (0.05 mmol) of bis(triphenylphosphine)palladium chloride. 360 mg of 4-[3-(3-tert-butyl-4-pyrrolidin-1-ylphenyl)-3-hydroxyprop-1-ynyl]benzoic acid are obtained in the form of a beige solid (Mp=150° C., yield=46%).

Provenance & Evidence