HCID 86646569, compound → HCID 86646570, compound

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 1 g (4 mmol) of 3-tert-butyl-4-piperidin-1-ylbenzaldehyde with 12 ml (6 mmol) of a 0.5M solution of ethynylmagnesium bromide. 890 mg of 1-(3-tert-Butyl-4-piperidin-1-ylphenyl)prop-2-yn-1-ol are obtained in the form of a colourless oil (yield=82%).

Provenance & Evidence