4-Iodobenzoic acid → HCID 25109629, compound

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 1.18 g (4.4 mmol) of 1-(3-tert-butyl-4-piperidin-1-ylphenyl)prop-2-yn-1-ol with 890 mg (3.6 mmol) of 4-iodobenzoic acid, 35 mg (0.18 mmol) of copper iodide and 63 mg (0.09 mmol) of bis(triphenylphosphine)palladium chloride. 650 mg of 4-[3-(3-tert-butyl-4-piperidin-1-ylphenyl)-3-hydroxyprop-1-ynyl]benzoic acid are obtained in the form of a beige solid (Mp=112° C., yield=46%).

Provenance & Evidence