Methyl 4-iodosalicylate → HCID 67276336, compound

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 3.7 g (15 mmol) of 1-(3-tert-butyl-4-diethylaminophenyl)prop-2-yn-1-ol with 3.3 g (12 mmol) of methyl 4-iodosalicylate, 114 mg (0.6 mmol) of copper iodide and 210 mg (0.3 mmol) of bis(triphenylphosphine)palladium chloride. 4 g of methyl 4-[3-(3-tert-butyl-4-diethylaminophenyl)-3-hydroxyprop-1-ynyl]-2-hydroxybenzoate are obtained in the form of yellow oil (yield=66%).

Provenance & Evidence