3-Tert-butyl-5-chloro-4-dimethylaminobenzaldehyde → 1-(3-Tert-butyl-5-chloro-4-dimethylaminophenyl)prop-2-yn-1-ol

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 13 ml (6.5 mmol) of 0.5M ethynylmagnesium bromide/THF with 1.2 g (5 mmol) of 3-tert-butyl-5-chloro-4-dimethylaminobenzaldehyde. 650 mg of 1-(3-tert-butyl-5-chloro-4-dimethylamino-phenyl)prop-2-yn-1-ol are obtained in the form of a yellow solid (yield=49%).

Provenance & Evidence