4-Dimethylamino-3,5-diisopropylbenzaldehyde → 1-(4-Dimethylamino-3,5-diisopropylphenyl)prop-2-yn-1-ol

Participants

Reaction Steps

In a manner analogous to example 1 e, the process is carried out by a reaction of 28 ml (14 mmol) of 0.5M ethynylmagnesium bromide/THF with 1.2 g (5 mmol) of 4-dimethylamino-3,5-diisopropylbenzaldehyde. 2.5 g of 1-(4-dimethylamino-3,5-diisopropylphenyl)prop-2-yn-1-ol are obtained in the form of a whitish solid (yield=90%).

Provenance & Evidence