HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Diethylamino-3-isopropylbenzaldehyde → 1-(4-Diethylamino-3-isopropylphenyl)prop-2-yn-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Diethylamino-3-isopropylbenzaldehyde | HCID 86646575 | — |
| Reactant | HCID 178462450 | HCID 178462450 | — |
| Product | 1-(4-Diethylamino-3-isopropylphenyl)prop-2-yn-1-ol | HCID 86646576 | 83.8% |
Reaction Steps
In a manner analogous to example 1 e, the process is carried out by a reaction of 9.3 ml (4.7 mmol) of 0.5M ethynylmagnesium bromide/THF with 780 mg (3.5 mmol) of 4-diethylamino-3-isopropylbenzaldehyde. 720 mg of 1-(4-diethylamino-3-isopropylphenyl)prop-2-yn-1-ol are obtained in the form of a yellow oil (yield=83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163952B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-852eb9d6920844f5aa413700470ec0e6 |
| Source note | uspto-grants-2012_04 |