4-Iodobenzoic acid → 4-[3-(4-Diethylamino-3-isopropylphenyl)-3-hydroxyprop-1-ynyl]benzoic acid

Participants

Reaction Steps

In a manner analogous to example 1 f, the process is carried out by a reaction of 248 mg (1 mmol) of 4-iodobenzoic acid with 350 mg (1.4 mmol) of 1-(4-diethylamino-3-isopropylphenyl)prop-2-yn-1-ol in the presence of 11 mg (0.06 mmol) of copper iodide and 20 mg (0.03 mmol) of bis(triphenylphosphine)palladium chloride. 240 mg of 4-[3-(4-diethylamino-3-isopropylphenyl)-3-hydroxyprop-1-ynyl]benzoic acid are obtained in the form of a whitish solid (Mp=145° C., yield=46%).

Provenance & Evidence