(2S,3S)-N-[(1S,2S)-2-hydroxycyclohexane-1-yl]-3-azido-2-hydroxyheptanamide → (2S,3S)-N-[(1S,2S)-2-hydroxycyclohexane-1-yl]-3-amino-2-hydroxyheptanamide

Participants

Reaction Steps

To 30 ml of a methanol solution containing 1.45 g (5 mmol) of (2S,3S)-N-[(1S,2S)-2-hydroxycyclohexane-1-yl]-3-azido-2-hydroxyheptanamide was added 150 mg of 5% palladium carbon, and the resulting mixture was stirred under hydrogen atmosphere for 18 hours. Insoluble material was filtered off, and the filtrate was distilled under reduced pressure to obtain 1.18 g (Yield: 91%) of the title compound.

Provenance & Evidence