(2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide → (2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-amino-2-hydroxyheptanamide

Participants

Reaction Steps

To 30 ml of a methanol solution containing 442 mg (1.27 mmol) of (2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide was added 45 mg of 5% palladium carbon, and the mixture was stirred under hydrogen atmosphere for 18 hours. Insoluble materials were filtered off, and the filtrate was distilled under reduced pressure to obtain 385 mg (Yield: 94%) of the title compound.

Provenance & Evidence