HCID 57959823, compound → HCID 57959866, compound

HRID 1698499Notes

Reaction equation

HRID 1698499 reaction equation
C(S(/N=C/[C@H]1CCCN1C(OC(C)(C)C)=O)=O)(C)(C)C.[NH2:21][CH:22]([C:35]1[CH:40]=[CH:39][C:38]([S:41][CH2:42][CH:43]2[CH2:45][CH2:44]2)=[CH:37][CH:36]=1)[C@@H:23]1[CH2:27][CH2:26][CH2:25][N:24]1[C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29]>>[NH2:21][CH:22]([C:35]1[CH:40]=[CH:39][C:38]([S:41][CH2:42][CH:43]2[CH2:45][CH2:44]2)=[CH:37][CH:36]=1)[C@H:23]1[CH2:27][CH2:26][CH2:25][N:24]1[C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29]

Participants

3

Reactant 2

HCID 57959823HCID 57959823, compoundHCID 178451938HCID 178451938, compound

Product 1

HCID 57959866HCID 57959866, compound

Procedure

The title compound was prepared from tert-butyl (2R)-2-{(E)-[(tert-butylsulphinyl)imino]methyl}pyrrolidine-1-carboxylate using conditions described in Examples 5 and 6 and with the Grignard reagent described in Example 7. Data identical to those described for tert-butyl (2S)-2-(amino{4-[(cyclopropylmethyl)thio]phenyl}methyl)pyrrolidine-1-carboxylate.

Sources & evidence

ORD record
ord-d5d4d46593104052a5b7c70d51192b8e
Source dataset
uspto-grants-2012_04
Patent number
US08163956B2

Reaction notes

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