Trifluoroacetate → HCID 12004350, compound

Participants

Reaction Steps

The title compound was prepared from (1S)-1-{5-[(cyclopropylmethyl)sulphinyl]-4-methyl-4H-1,2,4-triazol-3-yl}-2-morpholin-4-ylethanamine bis(trifluoroacetate and 2-methyl-6-(trifluoromethyl)nicotinoyl chloride using the conditions described in Example 65 steps f and g. 1H NMR (500 MHz, d6-DMSO) δ (ppm) 9.23 (1H, d, J=8.1 Hz), 7.99 (1H, d, J=7.9 Hz), 7.81 (1H, d, J=7.9 Hz), 5.57-5.53 (1H, m), 3.94 (3H, s), 3.65-3.51 (6H, m), 3.07 (1H, dd, J=9.4, 12.7 Hz), 2.90 (1H, dd, J=5.7, 12.8 Hz), 2.62 (3H, s), 2.61-2.58 (2H, m), 2.51-2.46 (2H, m), 1.06-0.98 (1H, m), 0.56-0.48 (2H, m), 0.22-0.14 (2H, m); m/z (ES+) 517 (M+H).

Provenance & Evidence