Phosphorus oxychloride → HCID 67273157, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 145 mg (0.514 mmol) of 7-(4-methoxybenzoyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one was dissolved in 1.5 mL of phosphorous oxychloride and heated at 100° C. for 18 h. The reaction was allowed to cool to room temperature and concentrated in vacuo. The residue thus obtained was dissolved in ethyl acetate, washed with aqueous sodium bicarbonate, dried over magnesium sulfate, filtered and concentrated in vacuo to give 124 mg (80%) of the title compound, which was used in the next step without further purification.

Provenance & Evidence