9-Nitro-2,3-dihydro-4,1-benzoxazepin-5(1H)-one → 9-Amino-2,3-dihydro-4,1-benzoxazepin-5(1H)-one

Participants

Reaction Steps

A solution of 500 mg (2.42 mmol) of 9-nitro-2,3-dihydro-4,1-benzoxazepin-5(1H)-one in 500 mL of methanol was inerted with nitrogen. To this solution was added 100 mg of 10% palladium on carbon (50% wet) and the reaction was purged with hydrogen and stirred under balloon pressure hydrogen for 6 h. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give 430 mg (99%) of the title compound.

Provenance & Evidence