Acetic Acid → HCID 67273117, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 211 mg (0.986 mmol) of 7-hydrazino-1-methyl-1,3-dihydro-2H-benzimidazol-2-one in 2 mL of acetic acid was added 0.13 mL (0.986 mmol) of 3,5-heptanedione, the mixture was stirred at 100° C. for 2 hours. After cooling, the reaction mixture was neutralized by saturated aqueous sodium hydrogen carbonate and extracted with ethyl acetate (X2). The combined organic layer was washed with brine (X1), dried over sodium sulfate and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with a 50-80% ethylacetate/n-hexane gradient mixture to give 221 mg (83%) of the title compound.

Provenance & Evidence