Methyl 2-amino-3-nitrobenzoate → 2,3-Diaminobenzoic acid methyl ester

Participants

Reaction Steps

To a suspension of methyl 2-amino-3-nitrobenzoate (15 g, 76.5 mmol) in methanol (800 mL) was added 10% palladium on carbon (50% wet; 6.5 g), and the mixture was stirred at room temperature for 20 hours under hydrogen atmosphere. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo. The residual solid was crystallized from diisopropyl ether-hexane to give 11.57 g (69.6 mmol, 91.0%) of the title compound as a dark yellow needle.

Provenance & Evidence