N-methyl-2-pyrrolidone → HCID 58012329, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-7-(1-ethylpropyl)-1-methyl-1H-benzimidazole-4-carbonitrile (1.00 g, 3.82 mmol), 4-chloro-2-methoxy-6-methylaniline (1.97 g, 11.50 mmol) and 1-methyl-2-pyrrolidone (0.5 ml) was heated at 130° C. for 48 h. After cooling, the reaction mixture was diluted with aqueous saturated sodium hydrogen carbonate. The mixture was extracted with ethyl acetate, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel to give the title compound as a white powder (670 mg, 44%).

Provenance & Evidence