HCID 70183495, compound → HCID 70182935, compound

Participants

Reaction Steps

(±)-2-tert-Butoxycarbonylamino-3-(2-nitrophenyl)-amin opropionic acid (325 mg) was dissolved in methanol (50 mL), followed by the addition of 10% palladium carbon (50 mg). The resulting mixture was stirred at room temperature for 1 hour under a hydrogen atmosphere. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure, whereby (±)-2-tert-butoxycarbonylamino-3-(2-aminophenyl)-aminopropi onic acid was obtained. It was suspended in toluene (30 mL) The suspension was refluxed for 3 hours while removing water by a Dean-Stark extractor. The resultant mixture was concentrated under reduced pressure. After the residue was purified by silica gel colomn chromatography (chloroform:methanol=20:1), diisopropyl ether was added thereto for crystallization. Crystals so precipitated were then collected by filtration, whereby the title compound (210 mg) was obtained. Yield: 76%.

Provenance & Evidence