HCID 9808474, compound → HCID 178447121, compound

HRID 1698771Notes

Reaction equation

HRID 1698771 reaction equation
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:11][C@@H:10]([NH:25][C:26](=[O:40])[NH:27][C:28]2[CH:29]=[C:30]([C:34]([CH3:39])([CH3:38])[C:35]([OH:37])=[O:36])[CH:31]=[CH:32][CH:33]=2)[C:9]1=[O:41])=[O:6])([CH3:4])([CH3:3])[CH3:2].[NH2:42][C@H:43]1[CH2:48][CH2:47][C@H:46]([OH:49])[CH2:45][CH2:44]1>C(#N)C>[NH2:42][C@H:43]1[CH2:48][CH2:47][C@H:46]([OH:49])[CH2:45][CH2:44]1.[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([CH:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)[CH2:11][C@@H:10]([NH:25][C:26](=[O:40])[NH:27][C:28]2[CH:29]=[C:30]([C:34]([CH3:39])([CH3:38])[C:35]([OH:37])=[O:36])[CH:31]=[CH:32][CH:33]=2)[C:9]1=[O:41])=[O:6])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 9808474HCID 9808474, compoundHCID 178511715HCID 178511715, compound

Product 1

HCID 178447121HCID 178447121, compoundYield 82.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

(R)-(−)-2-[3-[3-(1-tert-Butylcarbonylmethyl-2-oxo-5-c yclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)urei do]phenyl]-2-methylpropionic acid (42 mg) was dissolved in acetonitrile (0.5 mL). Trans-4-amino-cyclohexanol (8 mg) was added and then dissolved under heat. After the mixture was allowed to stand overnight, crystals so precipitated were collected by filtration and dried, whereby the title compound (39 mg) was obtained. Yield: 77%.

Workup

  1. dissolutiondissolved
  2. temperatureunder heat
  3. customcrystals so precipitated
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-174104e21bf942eca47009a7ca55e65e
Source dataset
uspto-grants-2002_02
Patent number
US06344452B1

Reaction notes

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