Benzathine → HCID 9832273, compound

HRID 1698772Notes

Reaction equation

HRID 1698772 reaction equation
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:11][C@@H:10]([NH:25][C:26](=[O:40])[NH:27][C:28]2[CH:29]=[C:30]([C:34]([CH3:39])([CH3:38])[C:35]([OH:37])=[O:36])[CH:31]=[CH:32][CH:33]=2)[C:9]1=[O:41])=[O:6])([CH3:4])([CH3:3])[CH3:2].[CH2:42]([NH:49][CH2:50][CH2:51][NH:52][CH2:53][C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1)[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1>C(#N)C>[CH2:42]([NH:49][CH2:50][CH2:51][NH:52][CH2:53][C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1)[C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=1.[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([CH:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)[CH2:11][C@@H:10]([NH:25][C:26](=[O:40])[NH:27][C:28]2[CH:29]=[C:30]([C:34]([CH3:39])([CH3:38])[C:35]([OH:37])=[O:36])[CH:31]=[CH:32][CH:33]=2)[C:9]1=[O:41])=[O:6])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 8793BenzathineHCID 9808474HCID 9808474, compound

Product 1

HCID 9832273HCID 9832273, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

(R)-(−)-2-[3-[3-(1-tert-Butylcarbonylmethyl-2-oxo-5-c yclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)urei do]phenyl]-2-methylpropionic acid (158 mg) and N,N′-dibenzylethylenediamine (67 mg) were added to acetonitrile (2 mL), and were then dissolved under heat. The reaction mixture was allowed to stand. Crystals so precipitated were collected by filtration and dried, whereby the title compound (200 mg) was obtained. Yield: 89%.

Workup

  1. dissolutionwere then dissolved
  2. temperatureunder heat
  3. customCrystals so precipitated
  4. filtrationwere collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-3fa4578bc3c549c8814f6d87e2bbdbd0
Source dataset
uspto-grants-2002_02
Patent number
US06344452B1

Reaction notes

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