Sodium Hydroxide → HCID 23690294, compound

HRID 1698773Notes

Reaction equation

HRID 1698773 reaction equation
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:11][C@@H:10]([NH:25][C:26](=[O:40])[NH:27][C:28]2[CH:29]=[C:30]([C:34]([CH3:39])([CH3:38])[C:35]([OH:37])=[O:36])[CH:31]=[CH:32][CH:33]=2)[C:9]1=[O:41])=[O:6])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+:43]>CO>[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([CH:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)[CH2:11][C@@H:10]([NH:25][C:26](=[O:40])[NH:27][C:28]2[CH:29]=[C:30]([C:34]([CH3:39])([CH3:38])[C:35]([O-:37])=[O:36])[CH:31]=[CH:32][CH:33]=2)[C:9]1=[O:41])=[O:6])([CH3:4])([CH3:2])[CH3:3].[Na+:43]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9808474HCID 9808474, compound

Product 1

HCID 23690294HCID 23690294, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (R)-(−)-2-[3-[3-(1 -tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)ureido]phenyl]-2-methylpropionic acid (960 mg) in methanol (10 mL), 1 N sodium hydroxide (1.79 mL) was added. The solution was concentrated under reduced pressure. The residue was purified through HP-20 (“Diaion”, product of Mitsubishi Chemical Corporation) by means of water and methanol. The thus-purified residue was lyophilized, whereby the title compound (900 mg) was obtained.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. customThe residue was purified through HP-20 (“Diaion”, product of Mitsubishi Chemical Corporation) by means of water and methanol

Sources & evidence

ORD record
ord-5e257dc476cb489c9863485dcab39fb6
Source dataset
uspto-grants-2002_02
Patent number
US06344452B1

Reaction notes

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