Ethyl chloroformate → HCID 68467805, compound

Participants

Reaction Conditions

Reaction Steps

To an ice cold solution of 0.5 grams (1.76 millimoles) grams of 2′, 3′-isopropylidene uridine in 10 ml pyridine, 2.64 mmoles (1.5 equivalents) of ethylchloroformate was added dropwise while stirring. The reaction was allowed to warm up to room temperature (25° C.) and stirred overnight (18 hours), at which point TLC (9:1 chloroform/methanol) showed complete conversion of starting material to a single product. The solvent was removed by rotary evaporation under high vacuum, giving a light beige syrup which was carried over into the subsequent deprotection step.

Provenance & Evidence