Hydrochloric Acid → HCID 18322312, compound

Participants

Reaction Conditions

Reaction Steps

11.53 g (165.9 mmol) of hydroxylamine hydrochloride are dissolved in 25 ml of water and, at a temperature of at most 0°C., admixed with a solution of 13.27 g (331.8 mmol) of sodium hydroxide in 60 ml of water. Without further cooling, 30.9 g (165.9 mmol) of ethyl 2-ethylhexan-3-onecarboxylate are then added in one portion, and the mixture is stirred at 50° C. for 3 h. For work-up, 15.5 ml of conc. hydrochloric acid are added at 0°C., and the mixture is diluted with water and extracted three times with dichloromethane. The organic phase is dried over sodium sulphate, concentrated and fractionated under high vacuum. B.p.2mbar 105-115°C.

Provenance & Evidence