反应详情

A 1.0 M solution of tetrabutylammonium fluoride in tetrahydrofuiran (26.6 mL, 26.6 mmol) was added to neat benzyl ester 24 (5.00 g, 13.3 mmol), the reaction stirred 10 minutes at ambient temperature, and evaporated in vacuo. The crude product was dissolved in methylene chloride, the solution washed with dilute aqueous NaHCO3, dried overNa2SO4, and filtered. The evaporated filtrate was then washed repeatedly with hexanes and dried in vacuo giving product 25 as a gold oil (3.40 g, 98%). 1H NMR (300 MHz, CDCl3) δ 7.35 (m, 7H), 7.1 (t, 1H, J=2.1 Hz), 5.28 (s, 2H).

1. customevaporated in vacuo
2. dissolutionThe crude product was dissolved in methylene chloride
3. washthe solution washed with dilute aqueous NaHCO3
4. customdried overNa2SO4, and
5. filtrationfiltered
6. washThe evaporated filtrate was then washed repeatedly with hexanes
7. customdried in vacuo