反应详情

8.9 ml of benzoyl chloride are added to a solution of 5.9 g of ammonium thiocyanate in 130 ml of anhydrous acetone. The reaction mixture is heated under reflux for 15 minutes and then after cooling, 10 g of 5-chloro-2-methylaniline are added. The reaction mixture is heated under reflux for 2 hours and the acetone is removed by distillation under vacuum. The residue obtained is taken up in dichloromethane. The mixture is washed with water, dried over sodium sulphate and evaporated under vacuum. The expected product is obtained in the form of an oil with a quantitative yield.

1. temperatureThe reaction mixture is heated
2. temperatureunder reflux for 15 minutes
3. temperatureafter cooling
4. temperatureThe reaction mixture is heated
5. temperatureunder reflux for 2 hours
6. customthe acetone is removed by distillation under vacuum
7. customThe residue obtained
8. washThe mixture is washed with water
9. dry with materialdried over sodium sulphate
10. customevaporated under vacuum