HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(2-chloro-4-methoxyphenyl)-propan-1-one → 4-(2-Chloro-4-methoxyphenyl)-5-methyl-2-[N-(5-carboxy-2-methoxyphenyl)-N-propylamino]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(2-chloro-4-methoxyphenyl)-propan-1-one | HCID 11054985 | — |
| Reactant | N-(2-methoxy-5-carboxyphenyl)-N-propylthiourea | HCID 18322253 | — |
| Product | 4-(2-Chloro-4-methoxyphenyl)-5-methyl-2-[N-(5-carboxy-2-methoxyphenyl)-N-propylamino]thiazole | HCID 18322262 | 70% |
Reaction Steps
By following the procedure of EXAMPLE 2 and by using 2-bromo-1-(2-chloro-4-methoxyphenyl)propan-1-one (Compound 1-2) and N-(2-methoxy-5-carboxyphenyl)-N-propylthiourea (Compound 12-1), the expected product is obtained in the form of white crystals; yield=70%; m.p.=109° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06344470B1 |
| Source dataset | uspto-grants-2002_02 |
| ORD ID | ord-71231d9df8924d728346af42ac7d3379 |
| Source note | uspto-grants-2002_02 |