HCID 18322365, compound → HCID 18322370, compound

Participants

Reaction Steps

To a solution of N-(2-carbobenzyloxy-5-tert-butyl-3-thienyl)-N′-(4-methylphenyl)urea (0.19 g, 0.40 mmol) in EtOH (19 mL) was added 10% Pd/C (0.010 g). The resulting suspension was treated with H2 (52 psi) in a Parr® shaker for 18 h. The slurry was filtered through a pad of Celite® and concentrated under reduced pressure to afford N-(2-carboxy-5-tert-butyl-3-thienyl)-N′-(4-methylphenyl)urea (0.12 g, 90%):1H NMR (d6-DMSO) δ13 (s, 9H), 2.2 (s, 3H), 7.1 (d, 2H), 7.4 (d, 2H), 7.8 (s, 1H); FAB-LRMS m/z) 333 (M+H).

Provenance & Evidence