Formamide → HCID 68468977, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 3-amino-7-nitrobenzothiophene-2-carboxylate (242 mg, 0.96 mmol) and formamidine acetate (0.51 g, 4.9 mmol) was heated up to 185° C. when 1.5 mL formamide was added to the reaction. After 1 hour at 185° C., the reaction was cooled to 25° C. The solid was collected and washed with water then dried. 6-Nitrobenzothieno [3,2-d]pyrimidone was isolated as a yellow solid (161.5 mg, 68%).

Provenance & Evidence