Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acrylic Acid | HCID 6581 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 68468203 | HCID 68468203 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 5328419 | HCID 5328419 | 30.8% |
Reaction Steps
To a solution of 6-amino-4-[(3-bromophenyl)amino]benzothieno-quinazoline (130 mg, 0.35 mmol), acrylic acid (0.05 mL, 0.73 mmol), and triethylamine (0.1 mL, 0.72 mmol) in DMF (3 mL) stirred under N2 at 0° C. was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (144 mg, 0.75 mmol). The reaction gradually warmed up to 25° C. and was quenched with water after 20 hours. The formed yellow solid was collected and purified by sonication with acetone to give the desired product (40 mg, 27%), mp 216.4-217.2° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06344459B1 |
|---|
| Source dataset | uspto-grants-2002_02 |
|---|
| ORD ID | ord-827324f3914f4176ad3d83d25c60e790 |
|---|
| Source note | uspto-grants-2002_02 |
|---|
