4-Methylmorpholine → HCID 86757766, compound

Participants

Reaction Steps

A solution of 7-methyl-{[4-(1-hydroxy-hexyl)-benzyl]-amino}-heptanoate (82.2 mg, 0.235 mmol), 1-propanesulfonyl chloride (29.1 RL, 0.259 mmol) and 4-methylmorpholine (28.5 μL, 0.259 mmol) in CH2Cl2 (10 mL) was stirred at room temperature for 24 h. Additional 1-propanesulfonyl chloride (14.5 μL) and 4-methylmorpholine (14.3 μL) were added, and the reaction was stirred for 5 days. The organic solution was washed consecutively with 5.5% HCl, water, aqueous NaHCO3, and brine. The organic solution was dried (MgSO4), filtered, and concentrated to yield 7-[[(4-(1-hydroxy-hexyl)-benzyl]-(propane-1-sulfonyl)-amino]-heptanoic acid methyl ester which was used in the next step without further purification.

Provenance & Evidence