反应详情

温度

140 °C

A suspension of 5-(4-chlorobenzyl)-5-cyano-2,2-dimethylcyclopentanone (5.0 g, 0.02 mole) in water is treated with sulfuric acid (50%, 25 ml), stirred for 5 hours at 140° C., cooled to room temperature, and extracted with toluene. The extracts are combined, washed with water, filtered through celite and concentrated in vacuo to afford the title product as a dark oil, 5.5 g (76.5% pure, 93.1% yield), identified by gas chromatography.

1. temperaturecooled to room temperature
2. extractionextracted with toluene
3. washwashed with water
4. filtrationfiltered through celite and
5. concentrationconcentrated in vacuo